Lens morphology in cataract patients with zonular dialysis by AS-OCT

To investigate the morphologic characteristics of lens in cataract patients with zonular dialysis (ZD) before and after cycloplegia by anterior-segment optical coherence tomography (AS-OCT).

Peking University Third Hospital, Beijing, China.

Cross-sectional observational study.

56 eyes from 56 participants who would undergo cataract operations were included, with 29 eyes of normal controls and 27 eyes of patients with ZD. Lens morphologic parameters were then evaluated by AS-OCT, including anterior chamber depth (ACD), lens thickness (LT), lens diameter, lens vault, anterior curvature radius, posterior curvature radius, decentration, and tilt of lens. After participants were treated with 3-time tropicamide solution, AS-OCT was repeated to acquire postcycloplegia results. SPSS 22.0 software was used for statistical analysis.

The comparison of basic lens morphologic parameters without cycloplegia found that only anterior curvature ( P = .039) showed significant differences between normal and ZD groups. AS-OCT measured after 30-minute cycloplegia treatment showed significantly increased ACD, larger lens diameter, larger posterior curvature and decreased vault in both groups, decreased LT in the normal group, and increased anterior curvature and decreased lens decentration in the ZD group (all P < .05). The logistic regression model showed the ZD group had greater alterations of ACD ( P = .014), anterior curvature ( P = .009), and decentration ( P = .031) after cycloplegia treatment when compared with the normal group.

Lens in patients with ZD was characterized by steeper anterior curvature and greater alterations of ACD, anterior curvature, and decentration after cycloplegia. The comparison of lens morphologic parameters before and after cycloplegia might be the potential method to evaluate the stability of zonular fibers.