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Updated: Sep 19, 2025

Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion
Published on: November 10, 2023
Pleural Fluid Analysis: Maximizing Diagnostic Yield in the Pleural Effusion Evaluation
Amit Chopra1, Kurt Hu2, David Feller-Kopman3
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Albany Medical Center, Albany, NY.
Abstract:
Establishing the cause of a pleural effusion can be challenging. Analysis of pleural fluid (PF) is a powerful tool to determine the cause of a pleural effusion. Surprisingly, despite the diagnostic power of PF analysis (PFA), it is often underused. This review provides a practical framework to maximize the diagnostic potential of the PFA. We describe the role of a PFA in establishing the cause of a pleural effusion. We also discuss challenges and limitations of PFA.
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