Related Experiment Video
Updated: Sep 19, 2025
Semi-Quantitative Analysis of Peptidoglycan by Liquid Chromatography Mass Spectrometry and Bioinformatics
Published on: October 13, 2020
Identification of non-canonical peptides with moPepGen
Chenghao Zhu1,2,3,4, Lydia Y Liu5,6,7,8,9, Annie Ha7,8
1Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA. chenghaozhu@mednet.ucla.edu.
None:
Proteogenomics is limited by the challenge of modeling the complexities of gene expression. We create moPepGen, a graph-based algorithm that comprehensively generates non-canonical peptides in linear time. moPepGen works with multiple technologies, in multiple species and on all types of genetic and transcriptomic data. In human cancer proteomes, it enumerates previously unobservable noncanonical peptides arising from germline and somatic genomic variants, noncoding open reading frames, RNA fusions and RNA circularization.
