Related Experiment Video
Updated: Sep 19, 2025
Application of an Amplitude-integrated EEG Monitor Cerebral Function Monitor to Neonates
Published on: September 6, 2017
Early outcome-prediction with an automated EEG background trend in hypothermia-treated newborns with encephalopathy
Karla Gonzalez-Tamez1, Saeed Montazeri2, Johan Ågren3
1Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. karla.gonzalez@uu.se.
Background:
Therapeutic hypothermia is an intervention that improves outcomes and alters early outcome-prediction in infants with moderate-severe hypoxic-ischemic encephalopathy (HIE). This study evaluated the early predictive accuracy of a fully automated continuous EEG background trend, Brain State of the Newborn (BSN) in a regional Swedish cohort of infants with presumed HIE.
Method:
The BSN trend characterizes 1-min segments of EEG from zero (inactive) to 100 (continuous) and was generated from aEEG/EEG in 85 infants treated with hypothermia. BSN trajectories were compared in relation to clinical grading of encephalopathy and outcome. Receiver operating characteristics were computed for good (no/mild impairment) and poor outcomes (moderate/severe impairment or death).
Results:
During the first 48 h, BSN levels differed significantly between moderate and severe HIE (typical median BSN levels >80 and <40, respectively). The predictive accuracy of BSN was high already at 6 h (AUC 0.84) and at 12 h (AUC 0.91), with corresponding positive predictive values (PPV) > 0.92 for good outcome (cutoff BSN > 80) and PPV > 0.95 for poor outcome (cutoff BSN < 40).
Conclusion:
BSN gives a continuous and objective measure of EEG background activity, which is highly predictive of good and poor outcomes already from the first 6-12 h in hypothermia-treated infants with moderate-severe HIE.
Impact:
Brain State of the Newborn (BSN) is a deep learning-based EEG trend displaying electrocortical activity as numerical values. Here we establish that BSN trends over the first 48 h differ between infants with moderate versus severe hypoxic-ischemic encephalopathy (HIE) and is highly predictive of long-term outcome. This is the first study applying BSN trends in a cohort of exclusively hypothermia-treated infants, demonstrating its value for outcome-prediction already from the first 12 h after birth. The BSN provides a continuous bedside evaluation of brain function that complements the visual aEEG/EEG review and can assist bedside assessments in neonatal intensive care units.
