Related Experiment Video
Updated: Sep 19, 2025
10:28
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
11.2K
99m Tc-FAPI-46 Scintigraphy in Genital Tract Carcinosarcoma
Nasrin Raeisi1,2, Amin Saber Tanha1,2, Kamran Aryana1
1Nuclear Medicine Research Center, Mashhad University of Medical Sciences (MUMS).
Clinical Nuclear Medicine
|June 17, 2025
Summary
This study highlights the effectiveness of 99mTc-FAPI-46 scintigraphy in detecting advanced genital tract carcinosarcoma, outperforming contrast-enhanced CT (CeCT) scans. It suggests fibroblast activation protein inhibitor (FAPI) imaging as a superior diagnostic tool and potential therapy.
Area of Science:
- Oncology
- Nuclear Medicine
- Medical Imaging
Background:
- Genital tract carcinosarcoma is a rare and aggressive malignancy.
- Accurate staging and detection of tumor extent, including peritoneal carcinomatosis, are crucial for treatment planning.
- Contrast-enhanced CT (CeCT) has limitations in visualizing certain tumor manifestations.
Purpose of the Study:
- To evaluate the diagnostic performance of 99mTc-FAPI-46 scintigraphy in a patient with recurrent genital tract carcinosarcoma.
- To compare FAPI-targeted imaging with CeCT in assessing tumor burden and peritoneal spread.
- To explore the potential of FAPI-targeted therapies like 177Lu-FAPI.
Main Methods:
- Case report of a 47-year-old woman diagnosed with high-grade mucinous adenocarcinoma, later revealed as carcinosarcoma.
- Post-surgical imaging using 99mTc-FAPI-46 scintigraphy and contrast-enhanced CT (CeCT).
- Histopathologic evaluation of surgical specimens.
Main Results:
- 99mTc-FAPI-46 scintigraphy showed heterogeneous uptake in tumoral masses and diffuse uptake in peritoneal carcinomatosis.
- CeCT failed to detect the peritoneal carcinomatosis identified by FAPI scintigraphy.
- Histopathology confirmed carcinosarcoma and peritoneal involvement.
Conclusions:
- FAPI-targeted imaging demonstrates superior diagnostic performance compared to CeCT for assessing tumor extent in genital tract carcinosarcoma.
- 99mTc-FAPI-46 scintigraphy is effective in detecting peritoneal carcinomatosis.
- 177Lu-FAPI presents a promising potential therapeutic strategy for this malignancy.
