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Risk of cardiovascular disease among cancer survivors: systematic review and meta-analysis

  • 0Institute of Haematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Eclinicalmedicine +

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June 17, 2025

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June 17, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Cancer survivors face a significantly higher risk of cardiovascular disease (CVD) and its subtypes. This meta-analysis highlights the urgent need for prioritized CVD risk assessment and management in this population.

Area Of Science

  • Cardiology
  • Oncology
  • Epidemiology

Background

  • Conflicting studies exist regarding the association between cancer and cardiovascular disease (CVD) risk.
  • Population-based cohort studies are crucial for understanding long-term health outcomes in cancer survivors.

Purpose Of The Study

  • To investigate the risk of CVD in cancer survivors compared to individuals without a cancer history.
  • To analyze the association between cancer and 17 specific CVD subtypes.

Main Methods

  • Systematic review and meta-analysis of prospective and retrospective cohort studies.
  • Searched major databases (PubMed, Embase, Web of Science, Scopus) from 1990 to 2025.
  • Pooled hazard ratios (HRs) for CVD and subtypes, conducting subgroup and meta-regression analyses.

Main Results

  • 160 studies with over 49 million participants were analyzed.
  • Cancer survivors showed a 47% increased risk of CVD (HR, 1.47).
  • Increased risk observed across all 17 CVD subtypes, notably venous embolism (HR, 3.07) and ischemic heart disease (HR, 1.13).

Conclusions

  • Cancer survivors have a significantly elevated risk of CVD and its subtypes.
  • Prioritize CVD risk evaluation and management for cancer survivors, especially males, younger individuals, and those with brain, hematological, respiratory, male genital, and breast cancers.
  • Findings support guideline updates for CVD prevention in cancer survivors, emphasizing public health relevance.

Keywords:

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