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Morin Mitigates Methamphetamine-Induced Neurotoxicity: Effects on Motor and Cognitive Function

Godson E Anyanwu1,2, Amarachukwu Vivian Umeano3, Vivian O Ojiakor1,4

  • 1Department of Anatomy, Faculty of Biomedical Sciences, Kampala International University, Kampala, Uganda.

Journal of Experimental Pharmacology
|June 17, 2025
PubMed
Abstract

Insights

Morin, a natural flavonoid, effectively reverses methamphetamine (METH)-induced neurotoxicity and improves motor and cognitive deficits in rats by reducing oxidative stress and inflammation.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Toxicology

Background:

  • Neurodegenerative diseases present significant public health challenges.
  • Methamphetamine (METH) exposure causes persistent neurological damage, including neuronal loss and functional deficits.
  • Identifying therapeutic agents to counteract METH-induced neurotoxicity is crucial.

Purpose of the Study:

  • To investigate the neuroprotective potential of Morin against METH-induced neurotoxicity.
  • To evaluate Morin's efficacy in reversing motor and cognitive impairments caused by METH.
  • To explore the underlying mechanisms of Morin's action, including its effects on oxidative stress and inflammation.

Main Methods:

  • Adult rats were exposed to METH and subsequently treated with varying doses of Morin or fluoxetine.
  • Neurobehavioral tests assessed motor and cognitive functions.
  • Biochemical assays measured oxidative stress markers, inflammatory cytokines, dopamine, and acetylcholine.
  • Histological and immunohistochemical analyses examined neuronal integrity in the basal ganglia.

Main Results:

  • METH exposure led to increased oxidative stress, inflammation, altered neurotransmitter levels, and impaired motor/cognitive functions, with associated neuronal loss.
  • Morin administration dose-dependently ameliorated METH-induced neurobehavioral deficits and neuronal damage.
  • Morin treatment significantly reduced oxidative stress and inflammatory markers in METH-exposed rats.

Conclusions:

  • Morin demonstrates significant neuroprotective effects against METH-induced neurotoxicity.
  • Morin mitigates METH-induced neurological damage by reducing oxidative stress and suppressing inflammation.
  • Morin shows potential as a therapeutic agent for addressing the neurological consequences of methamphetamine misuse.
Keywords:
Morinacetylcholinecognitive functiondopaminemethamphetaminemotor functionneurodegenerationneurotoxicity

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