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Primary Cardiac Diffuse Large B-Cell Lymphoma Managed With Rituximab, Etoposide, Prednisone, Vincristine,

Jody W Tai1, Elliot N Roufeh1, Jarred P Reed2

  • 1Internal Medicine, Olive View University of California Los Angeles Medical Center, Los Angeles, USA.

Cureus
|June 17, 2025
PubMed

Insights

Primary cardiac lymphoma, a rare form of Diffuse Large B-cell Lymphoma (DLBCL), can present with cardiac symptoms. Prompt diagnosis and R-EPOCH chemotherapy can lead to remission and improved outcomes.

Area of Science:

  • Cardiology
  • Oncology
  • Hematology

Background:

  • Diffuse Large B-cell Lymphoma (DLBCL) is the most common non-Hodgkin's lymphoma subtype.
  • Primary cardiac involvement by DLBCL is exceptionally rare.
  • Cardiac lymphoma often presents with subtle, atypical symptoms, complicating diagnosis.

Observation:

  • A 60-year-old male presented with intermittent palpitations.
  • Palpitations were diagnosed as ventricular tachycardia.
  • Cardiac imaging revealed a right ventricular mass, confirmed as DLBCL via biopsy.

Findings:

  • The patient received R-EPOCH chemotherapy (rituximab, etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin).
  • Treatment led to symptomatic resolution of palpitations.
  • A significant reduction in the cardiac mass size was observed.

Implications:

  • Early detection of primary cardiac lymphoma is vital for improving patient survival.
  • An interdisciplinary approach is essential for managing this rare cardiac malignancy.
  • This case underscores the importance of considering lymphoma in cardiac masses with atypical presentations.

Keywords:
cardiac lymphomacardiac tumorsdiffuse large b-cell lymphomar-epochventricular tachycardia (vt)

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