Related Experiment Video
Updated: Sep 19, 2025

Multilevel Oblique Lumbar Interbody Fusion in Degenerative Lumbar Disc Disease with Instability
Published on: July 25, 2025
Opioid Dose Reduction Vis-à-Vis Lumbar Medial Branch Intervention
David H Rustom1, Alexander A Restum2, Kevin F Henry3
1Pain Management, Wayne State University Detroit Medical Center, Detroit, USA.
Lumbar facet arthropathy (LFA) pain can be reduced by lumbar medial branch blocks (LMBBs) and radiofrequency ablation (RFA). These procedures significantly decreased prescription opioid use in patients with LFA.
Area of Science:
- Pain Medicine
- Interventional Pain Management
- Spine Surgery
Background:
- Lumbar facet arthropathy (LFA) is a degenerative condition causing chronic low back pain, particularly in individuals over 40.
- Osteoarthritis-like changes, including bony overgrowth and synovial cysts, characterize LFA.
- The L4/L5 and L5/sacral junctions are most commonly affected in the lumbar spine.
Purpose of the Study:
- To investigate the association between lumbar medial branch blocks (LMBBs) and radiofrequency ablations (RFAs) and the reduction in prescription opioid use.
- To evaluate the effectiveness of LMBBs and RFAs in managing pain associated with LFA.
Main Methods:
- A retrospective cohort study of 526 patients with documented LFA was conducted.
- Patients underwent LMBB, RFA, or a combination of both procedures.
- Morphine-equivalent opioid prescriptions were compared before and after the interventions using a paired t-test.
Main Results:
- Statistically significant reductions in prescription opioid use were observed after LMBB or combined LMBB and RFA procedures.
- Patients undergoing LMBB showed a mean reduction of 4.06 mg in opioid equivalence dose.
- Patients receiving both LMBB and RFA experienced a greater mean reduction of 6.10 mg.
Conclusions:
- LMBB and RFA procedures are effective in reducing prescription opioid use in patients with LFA.
- The combination of LMBB and RFA may offer enhanced reduction in opioid consumption.
- These interventions show potential for decreasing pain and the associated healthcare burden of LFA.
Related Concept Videos
Local Anesthetics: Clinical Application as Spinal Anesthesia
Analgesia and Pain Management
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Opioid Analgesics: Morphine and Other Natural Cogeners

