Preliminary studies of the histopathological responses to Ti-13% Cu casting alloys

A preliminary study of some of the biological properties of a new dental casting alloy (Ti-13% Cu) was undertaken by employing the skeletal muscle implantation test in rabbits. Routine histopathological and chemical analysis techniques were utilized to study in vivo tissue reactions of skeletal muscle to this alloy. A moderately thick, somewhat cellular fibrous connective tissue capsule surrounded the implants after 2 wk. Remodelling of the fibrous tissue into a thin acellular tissue capsule occurred at 52 wk after implantation. Chemical analyses failed to detect deposition of either Ti or Cu corrosion products at the implant sites or within major organs.