High O₂ tolerant metal-based catalysts for selective H₂O₂ reduction by constructing an ultra-thin oxide passivation...

Area of Science:

• Electrochemistry
• Materials Science
• Biomedical Engineering

Background:

• Hydrogen peroxide (H2O2) is crucial in disease biomarker detection.
• Existing H2O2 reduction catalysts are limited by interference from the oxygen reduction reaction (ORR).

Purpose of the Study:

• To develop a selective and sensitive electrochemical sensing platform for H2O2 detection.
• To overcome the limitations of ORR interference in H2O2 sensing.

Main Methods:

• Fabrication of a noble metal/tin oxide (NM/SnO2) sensing platform using atomic layer deposition (ALD).
• Utilizing an ultra-thin SnO2 passivation layer to inhibit O2 diffusion.
• Development of bioassay systems for biomarker detection.

Main Results:

• The NM/SnO2 platform demonstrated remarkable ORR tolerance and enhanced selectivity for H2O2 detection.
• Successful development of bioassays for glucose, lactate, and choline detection.
• The amorphous SnO2 layer effectively blocked O2 diffusion.

Conclusions:

• A straightforward and controllable strategy for ORR-tolerant H2O2 reduction catalysts was established.
• The developed sensing platform shows significant potential for electroanalysis and clinical diagnosis.
• This method offers improved accuracy and sensitivity in detecting multiple biomarkers.