Biocompatibility testing of prosthetic implant materials by cell cultures

The main aspects of biocompatibility are discussed first then the methodology used and the results obtained. The cells used included epithelial cells, lymphocytes, fibroblasts, and macrophages. The most commonly used methods were morphological observation, radioactive tracer uptake, and chemotactic migration analysis. It is concluded that cell cultures are a reliable and sensitive method for initial screening in testing the biocompatibility of the materials used in the construction of prosthetic implants.