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Accurate determination of enantiomeric excess of an amino acid using an extended-gate-type organic transistor

  • 0Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8505, Japan. tminami@g.ecc.u-tokyo.ac.jp.
Flow (cambridge, England) +

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June 17, 2025

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June 17, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

A novel chiral sensor using an organic field-effect transistor selectively identifies L-histidine. This device accurately measures enantiomeric excesses, distinguishing it from other amino acids.

Area Of Science

  • Materials Science
  • Analytical Chemistry
  • Biomedical Engineering

Background

  • Chiral recognition is crucial in pharmaceuticals and biochemistry.
  • Developing selective sensors for amino acids remains a challenge.
  • Organic field-effect transistors (OFETs) offer potential for sensitive detection.

Purpose Of The Study

  • To develop a chiral sensor for L-histidine detection.
  • To functionalize an extended-gate OFET with molecularly imprinted polymers (MIPs).
  • To demonstrate the sensor's ability to discriminate L-histidine from other amino acids.

Main Methods

  • Fabrication of an extended-gate organic field-effect transistor.
  • Functionalization of the transistor gate with a molecularly imprinted polymer selective for L-histidine.
  • Electrochemical measurements to assess chiral selectivity and enantiomeric excess determination.

Main Results

  • The functionalized OFET exhibited high chiral selectivity towards L-histidine.
  • The sensor successfully discriminated L-histidine from other amino acids.
  • The device enabled simultaneous determination of four data points for enantiomeric excesses.

Conclusions

  • The MIP-functionalized OFET is a promising platform for chiral amino acid sensing.
  • This technology can be applied to enantiomeric excess analysis in complex samples.
  • The developed sensor offers a novel approach for chiral drug and metabolite monitoring.

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