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An underrated clinical tool: CBC-derived inflammation indices as a highly sensitive measure of systemic immune

Victor Geller1, Marzena Dominiak1

  • 1Department of Oral Surgery, Wroclaw Medical University, Poland.

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University
|June 17, 2025
PubMed

Insights

Complete blood count-derived inflammation indices (CBC-DIIs) offer a sensitive and cost-effective method for assessing systemic inflammation. These indices show promise for evaluating immune response in clinical settings.

Area of Science:

  • Hematology
  • Immunology
  • Clinical Diagnostics

Background:

  • Systemic inflammation and immune response are critical indicators of health status.
  • Traditional biomarkers for inflammation can be expensive and complex.
  • Complete blood count (CBC) is a routine and widely accessible laboratory test.

Discussion:

  • Complete blood count-derived inflammation indices (CBC-DIIs) leverage existing CBC data.
  • These indices offer a novel, cost-effective approach to quantifying systemic inflammation.
  • CBC-DIIs have the potential to serve as sensitive markers of immune system activity.

Key Insights:

  • CBC-DIIs provide a practical tool for monitoring inflammation.
  • Their cost-effectiveness makes them suitable for broad clinical application.
  • These indices enhance the diagnostic utility of standard blood tests.

Outlook:

  • Further research is needed to validate CBC-DIIs across diverse clinical conditions.
  • Integration of CBC-DIIs into routine practice could improve patient management.
  • Future studies may explore the predictive value of these indices in various diseases.

Keywords:
CBC parametersCBC-derived indicescomplete blood countimmune responsesystemic inflammation

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