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Related Experiment Video

Updated: Sep 19, 2025

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Asymmetric Cingulum Bundle Connectivity Is Modulated by Paracingulate Sulcus Morphology.

Isabel A Danstrom1, Joshua A Adkinson1, Meghan E Robinson1,2

  • 1Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, USA.

Human Brain Mapping
|June 17, 2025
PubMed
Summary

The cingulum bundle's (CB) brain connectivity is influenced by the paracingulate sulcus (PCS) morphology. PCS presence impacts left CB connectivity, while its absence strengthens right CB engagement, suggesting lateralized modulation.

Keywords:
brain connectivitycingulum bundleparacingulate sulcussEEGsingle‐pulse electrical stimulation

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Area of Science:

  • Neuroscience
  • Neuroanatomy
  • Brain Connectivity

Background:

  • The cingulum bundle (CB) is crucial for brain network connectivity in health and disease.
  • The paracingulate sulcus (PCS) is a common anatomical feature, yet its effect on CB white matter remains unclear.

Purpose of the Study:

  • To define the electrographic connectivity profile of the CB.
  • To investigate how PCS morphology influences CB engagement and network interactions.

Main Methods:

  • Utilized single-pulse electrical stimulation and stereo-EEG recordings in 19 epilepsy patients.
  • Measured neural responses to left and right CB stimulation.
  • Calculated connectivity robustness ratios and compared network responses based on PCS morphology.

Main Results:

  • CB electrographic connectivity shows a leftward dominance.
  • PCS morphology significantly impacts CB engagement in both hemispheres.
  • Maximal left CB connectivity occurred with left PCS presence; maximal right CB connectivity occurred with left PCS absence.

Conclusions:

  • Bilateral CB engagement is modulated by PCS morphology, particularly in the left hemisphere.
  • Findings are relevant for understanding brain networks and targeting the CB in neuropsychiatric disorders.