[Characteristics of the activation of rabbit platelets induced by 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine...

A study was made of the action of alkyl acetylglycerophosphocholine, a semi-synthetic platelet activation factor. The compound was shown to have both marked aggregation activity and to interact with serotonin granules (5-HT-organelles) of the cells, inducing the release of the fluorescent marker acridine orange. Some features of the platelet aggregation factor interaction with platelet rich plasma suggest that the latter contains enzymes inducing degradation of the factor.