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Exploring Mirena use in association with symptoms at midlife
Ava Warner1, Sofiya Shreyer1, Daniel E Brown2
1Department of Anthropology, UMass Amherst, Amherst, MA.
Menopause (New York, N.Y.)
|June 17, 2025
Summary
Mirena IUD use showed no link to increased midlife symptoms like hot flashes or mood changes. This suggests the intrauterine device is unlikely to negatively impact symptom experience during menopause transition.
Area of Science:
- Reproductive Health
- Menopause Studies
- Women's Health Research
Background:
- The Mirena intrauterine device (IUD) is commonly used for heavy menstrual bleeding and contraception.
- Menopause transition involves various symptoms, including vasomotor, psychological, and musculoskeletal issues.
- Understanding the impact of hormonal contraception on menopausal symptoms is crucial for women's health.
Purpose of the Study:
- To investigate the association between Mirena IUD use and the experience of vasomotor, psychological, musculoskeletal, and sexual symptoms.
- To determine if Mirena IUD use increases symptom likelihood during the menopause transition.
Main Methods:
- Utilized data from 274 participants aged 45-55.
- Examined symptom prevalence in 23 Mirena IUD users (8%) and non-users.
- Employed logistic regression to analyze Mirena's relationship with specific symptoms (hot flashes, night sweats, leg cramps, aches, depressed mood), adjusting for age and BMI.
Main Results:
- No significant relationships were found between Mirena IUD use and midlife symptom experience.
- Higher Body Mass Index (BMI) was associated with increased likelihood of hot flashes, night sweats, and leg cramps.
Conclusions:
- Mirena IUD use does not appear to adversely affect symptom experience in midlife women.
- Findings suggest Mirena is unlikely to worsen symptoms related to menopause transition, regardless of its indication (menstrual bleeding, contraception, or other menstrual issues).
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