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Automated Dissection Protocol for Tumor Enrichment in Low Tumor Content Tissues
Published on: March 29, 2021
Streamlining and Accelerating the Molecular Tumor Board Process at the University Medical Center Hamburg-Eppendorf
Layla Tabea Riemann1, Maximilian Ataian2, Felicia P S Hähner2
1Institute for Applied Medical Informatics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. l.riemann@uke.de.
Background:
We developed, introduced, and evaluated Molecular ONcology Optimized CLinical Evaluation (MONOCLE), a secure, open-source web application at the University Medical Center Hamburg-Eppendorf (UKE), to optimize the analysis and discussion of complex cancer cases in molecular tumor boards (MTB).
Objective:
MONOCLE standardizes and harmonizes documentation, while its integrated Knowledge Connector accelerates literature research for personalized treatment.
Patients And Methods:
The system was designed by merging the requirements of the German Network for Personalized Medicine (DNPM), the medical staff involved in the MTB process, and the team developing MONOCLE. The usability was evaluated using the System Usability Scale (SUS) and user tasks. Overall process optimization was measured by the number of automated tasks that can be performed.
Results:
MONOCLE, introduced into clinical practice in June 2024, significantly reduces time for documentation, as three manual steps now run automatically, and transfer of the data to the DNPM is possible. Its usability and SUS showed positive results, ranging between 92.5 and 97.5.
Conclusions:
As the first open-source and extendable solution for standardized MTB documentation, MONOCLE enables wider adoption by other medical centers.
