Projected Trends in Metabolic Dysfunction-Associated Steatotic Liver Disease Mortality Through 2040
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View abstract on PubMed
Summary
This summary is machine-generated.Metabolic dysfunction-associated steatotic liver disease (MASLD) mortality in the US has risen significantly from 2006-2023 and is projected to increase. Disparities are most pronounced in older adults, White and Hispanic individuals, and nonmetropolitan populations.
Area Of Science
- Hepatology
- Public Health
- Epidemiology
Background
- Limited population-based data exists for metabolic dysfunction-associated steatotic liver disease (MASLD)-related mortality trends and forecasts in the United States.
- MASLD is a growing public health concern with significant morbidity and mortality implications.
Purpose Of The Study
- To examine MASLD-related mortality trends in the United States from 2006 to 2023.
- To forecast MASLD mortality rates up to 2040 overall and in subgroups by age, sex, race and ethnicity, and urbanization.
Main Methods
- A cross-sectional study utilizing the National Vital Statistics System dataset.
- Analysis of deaths attributed to MASLD in adults aged 25 years and older from 2006 to 2023.
- Evaluation of trends using average annual percentage change (AAPC) in age-standardized mortality rates (ASMRs) and projection models for forecasting.
Main Results
- MASLD-related mortality increased from 0.25 to 1.27 per 100,000 persons between 2006 and 2023, with AAPCs peaking between 2018-2021.
- The steepest ASMR rise was observed in individuals aged 65 years and older, with projected increases to 7.12 per 100,000 by 2040.
- Significant ASMR increases were noted across all racial and ethnic groups, particularly in non-Hispanic White and Hispanic individuals, and in nonmetropolitan areas.
Conclusions
- MASLD-related mortality has shown a rapid increase in the US from 2006 to 2023.
- Mortality rates are projected to continue rising over the next two decades.
- Significant disparities in MASLD mortality exist among older adults, specific racial/ethnic groups, and in nonmetropolitan populations, highlighting the need for targeted interventions.
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