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Updated: Sep 19, 2025

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
Published on: January 31, 2018
"Yin-Yang" of PARP1 in genotoxic and inflammatory response
Sijia Wang1, Yukang Wu1, Wen Zong1
1State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, PR China.
Abstract:
Poly(ADP-ribose) polymerase 1 (PARP1), the founding member of the PARP superfamily, is an enzyme with poly-ADP-ribosyltransferase activity that conducts the majority of poly-ADP-ribosylation (PARylation). PARP1 is the most extensively studied member of the PARP family. It plays a role in various biological processes, particularly in DNA damage repair, including base excision repair, single-strand break repair, double-strand break repair, and maintenance of replication fork stability. Besides DNA damage repair, PARP1 is also involved in the inflammatory response, including, but not limited to, the NF-κB, JAK-STAT, inflammasome assembly, and cGAS-STING signaling pathways. As a scaffold and enzyme, PARP1 and its mediated PARylation induce genotoxic and inflammatory responses to various intracellular and extracellular stressors. Thus, PARP1 has been a target as a pharmaceutical intervention for a range of pathological conditions, including cancer and inflammatory diseases. This review article attempts to provide a comprehensive view of PARP1 as a bridging point between genotoxic and inflammatory responses.
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