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Updated: Sep 19, 2025

Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin
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Progranulin function and regulation in the CNS.

Benjamin E Life1, Blair R Leavitt2

  • 1Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, BC V6H 0B3, Canada.

Trends in Neurosciences
|June 17, 2025
PubMed
Summary

Dysregulated progranulin expression impacts central nervous system (CNS) diseases. This review details progranulin's roles in cell signaling, lysosomal function, and immune processes, highlighting therapeutic strategies for CNS disorders.

Keywords:
Alzheimer's diseasecell signalingfrontotemporal dementianeurodegenerationreceptortherapeutic

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