Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Memory impairments following basal forebrain lesions.

D J Hepler, G L Wenk, B L Cribbs

    Brain Research
    |October 28, 1985
    PubMed
    Summary

    The nucleus basalis magnocellularis (NBM) and medial septal area (MSA) play crucial roles in memory formation. Lesions in these brain regions significantly impair performance across various memory-dependent tasks.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Rapamycin inhibits mTOR/p70S6K activation in CA3 region of the hippocampus of the rat and impairs long term memory.

    Neurobiology of learning and memory·2016
    Same author

    Differential rescue of spatial memory deficits in aged rats by L-type voltage-dependent calcium channel and ryanodine receptor antagonism.

    Neuroscience·2014
    Same author

    Mnemonic dissociations: the power of parameters.

    Journal of cognitive neuroscience·2013
    Same author

    Assessment of spatial memory.

    Current protocols in toxicology·2010
    Same author

    [(3)H]ketanserin binding increases in monkey cortex following basal forebrain lesions with ibotenic acid.

    Neurochemistry international·2010
    Same author

    New neuron production can be increased in the hippocampus of aged rats following cannabinoid treatment.

    Molecular psychiatry·2009

    Area of Science:

    • Neuroscience
    • Cognitive Science
    • Behavioral Neuroscience

    Background:

    • The nucleus basalis magnocellularis (NBM) and medial septal area (MSA) are key cholinergic brain regions implicated in cognitive functions.
    • Understanding their specific contributions to memory is essential for elucidating neural mechanisms of learning and memory.

    Purpose of the Study:

    • To investigate the functional role of the NBM and MSA in memory using a battery of behavioral tasks.
    • To compare the effects of NBM and MSA lesions on different types of memory and learning.

    Main Methods:

    • Bilateral ibotenic acid (IBO)-induced lesions of the NBM or MSA in rats.
    • Evaluation of lesioned and control rats in four distinct behavioral tasks: T-maze win-stay spatial discrimination, radial arm maze win-shift spatial discrimination, active avoidance, and passive avoidance.

    Main Results:

    • Rats with NBM or MSA lesions exhibited significantly impaired choice accuracy in both spatial discrimination tasks (T-maze and radial arm maze).
    • Lesioned rats showed altered learning rates in avoidance tasks, with impaired acquisition in active avoidance and increased trials to criterion in passive avoidance.
    • Behavioral deficits were consistent across tasks varying in motivation, reinforcement, and response requirements, suggesting a general memory impairment.

    Conclusions:

    • Both the NBM and MSA are critically involved in memory processes.
    • Lesions in either region produce comparable behavioral deficits, indicating overlapping functional contributions to memory.
    • These findings highlight the importance of these cholinergic nuclei in diverse aspects of learning and memory.

    Related Experiment Videos