ANCA-associated vasculitis after hantavirus infection: A case report

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a small and medium-vessel vasculitis that often leads to rapidly progressive glomerulonephritis. Although certain infections have been associated with ANCA formation, their role in triggering AAV is not fully understood.

A 60-year-old male who tested positive for hantavirus initially presented with fever, cough, and skin rash. Despite treatment with antibiotics for community-acquired pneumonia, his condition worsened, revealing elevated serum creatinine and proteinuria. Subsequent testing identified a significant increase in hantavirus antibody titers and positive anti-myeloperoxidase ANCA antibodies.

Laboratory tests and subsequent renal biopsy confirmed AAV with hantavirus infection.

Oral cyclophosphamide and high-dose glucocorticoids were initiated.

The patient's renal function deteriorated after immunosuppressive treatment, necessitating maintenance hemodialysis.

This is the first reported case of AAV following hantavirus infection, underscoring the need for vigilance in distinguishing AAV from other conditions in patients with viral infections.