Related Experiment Video
Updated: Sep 19, 2025
07:32
Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
Published on: February 17, 2021
7.6K
Skin health and biological aging.
David Furman1,2,3,4, Johan Auwerx5,6, Anne-Laure Bulteau7
1Stanford 1000 Immunomes Project, Stanford School of Medicine, Stanford, CA, USA. dfurman@buckinstitute.org.
Nature Aging
|June 17, 2025
Summary
Environmental exposures can accelerate biological aging. The skin acts as a window to understand the exposome
Area of Science:
- Environmental health
- Dermatology
- Aging research
Background:
- Biological aging can be accelerated by environmental exposures, known as the exposome.
- The skin, being the largest exposed organ, serves as a critical interface for studying exposome effects on aging.
Purpose of the Study:
- To review the interactions between skin exposure, aging hallmarks, and systemic aging.
- To explore the bidirectional relationship between skin aging and systemic hallmarks of aging.
- To identify potential therapeutic targets and strategies for preventing accelerated biological aging.
Main Methods:
- Literature review focusing on the exposome, skin aging, and systemic aging.
- Analysis of the interplay between skin aging hallmarks and systemic aging processes.
- Discussion of implications for treatment and disease management.
Main Results:
- The skin reflects exposome-induced aging and influences systemic aging.
- A bidirectional relationship exists between skin aging and systemic hallmarks of aging.
- Understanding these interactions offers avenues for preventing accelerated aging and developing therapies.
Conclusions:
- The skin is a key organ for understanding the exposome's impact on aging.
- Targeting skin aging may offer systemic health benefits.
- Development of precise biomarkers and advanced skin models is crucial for future research and interventions.
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