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Updated: Jul 16, 2026

Cryo-electron Microscopy Specimen Preparation By Means Of a Focused Ion Beam
Published on: July 26, 2014
Reduction of metal artifact from cryoprobe using tilt CT scanning with metal artifact reduction algorithms for
Tomohiro Inoue1, Noriyuki Umakoshi2, Yusuke Matsui3
1Department of Medical Support, Division of Radiology, Okayama University Hospital, Okayama, Japan. inoue-tmhr@okayama-u.ac.jp.
Abstract:
Computed tomography (CT) is a simple and useful method for monitoring during cryoablation; however, image quality is degraded by artifacts caused by the cryoprobe used during treatment. We evaluated the effectiveness of combining tilt scanning and single-energy metal artifact reduction (SEMAR) to improve image quality. A cryoprobe was inserted into an agar phantom, and CT scans were performed at various angles (0°, 5°, 10°, 15°, and 20°) with and without metal artifact reduction. The relative artifact index, calculated using the CT value standard deviation, was used to evaluate the intensity. The strongest tip artifacts occurred at 0°. The relative artifact index decreased with increasing tilt angles. The tilted scanning reduced artifacts extending beyond the cryoprobe tip, but SEMAR demonstrated a limited effect on artifact reduction. The tilted scanning method may be a useful approach for improving the image quality around the cryoprobe without increasing the exposure dose.

