Molecular Mechanisms Behind Organ-Related Aging and Regulatory Effects of Natural Therapeutics
Rimsha Abaidullah1, Shaukat Ali2, Muhammad Summer1
1Medical Toxicology and Biochemistry Laboratory, Department of Zoology, Government College University, Lahore, 54000, Pakistan.
Abstract:
Aging as a complex process is marked by physiological and functional deterioration, making the individual vulnerable to age-related diseases. Different organs experience unique aging processes that lead to conditions such as cardiovascular, cancer, metabolic, and musculoskeletal disorders. Understanding of these processes is essential to formulate effective interventions. To this end, plant-derived bio-actives are effective antiaging agents due to their specific mechanism of action. Phytochemicals in these plants possess antioxidant, anti-inflammatory, and senolytic activities that qualify them as good candidates for antiaging interventions. These molecules are also reported to act on important aging pathways such as immunomodulation, control of inflammation, reduction of oxidative stress, and senescence. The current review emphasizes the organ-specific mechanisms of aging and the role of certain plant constituents that have shown promising antiaging activity. By overviewing the natural interventions against aging mechanisms, this review provides a foundation for future research focused on using natural antiaging interventions involving phytochemicals.
Insights
Plant compounds offer promising antiaging effects by targeting organ-specific aging processes. These natural molecules combat inflammation and oxidative stress, supporting healthy aging interventions.
Area of Science:
- Gerontology and Molecular Biology
- Pharmacology and Natural Products
Background:
- Aging is a complex process involving physiological deterioration and increased vulnerability to age-related diseases.
- Distinct aging mechanisms occur in different organs, contributing to conditions like cardiovascular, metabolic, and musculoskeletal disorders.
Purpose of the Study:
- To review organ-specific aging mechanisms.
- To explore the potential of plant-derived bioactive compounds (phytochemicals) as antiaging interventions.
Main Methods:
- Literature review focusing on aging pathways and phytochemical activities.
- Analysis of scientific literature on plant constituents with antioxidant, anti-inflammatory, and senolytic properties.
- Examination of phytochemicals targeting immunomodulation, inflammation, oxidative stress, and senescence.
Main Results:
- Phytochemicals exhibit antioxidant, anti-inflammatory, and senolytic activities beneficial for antiaging.
- These compounds modulate key aging pathways, including immune function and cellular senescence.
- Specific plant constituents show promise in addressing organ-specific aging processes.
Conclusions:
- Plant-derived bioactive compounds are effective antiaging agents due to their targeted mechanisms.
- Phytochemicals offer a natural approach to interventions against aging and age-related diseases.
- Further research into natural antiaging interventions involving phytochemicals is warranted.
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