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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
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Unsuccessful aortic fenestration for aortic dissection complicated with mesenteric malperfusion analyzed using
Shoki Iwanaga1, Naoyuki Kimura2, Shuta Imada3
1Department of Surgery, Division of Cardiovascular Surgery, Jichi Medical University, Yakushiji 3311-1, Shimotsuke, 329-0498, Japan.
General Thoracic and Cardiovascular Surgery Cases
|June 17, 2025
Summary
Computational fluid dynamics (CFD) analysis revealed that a large entry tear and residual stenosis after fenestration for aortic dissection can lead to persistent false lumen flow and worsen mesenteric malperfusion.
Area of Science:
- Cardiovascular Surgery
- Medical Imaging
- Computational Fluid Dynamics
Background:
- Open fenestration for aortic dissection with mesenteric malperfusion is a complex procedure.
- Mesenteric malperfusion is a critical complication of aortic dissection.
Purpose of the Study:
- To analyze the hemodynamics of an unsuccessful open fenestration for aortic dissection using CFD.
- To identify the factors contributing to persistent mesenteric malperfusion after surgical intervention.
Main Methods:
- Case presentation of a 75-year-old male with acute type B aortic dissection and mesenteric malperfusion.
- Surgical infrarenal fenestration and prosthetic graft replacement for concomitant abdominal aneurysm.
- Post-intervention CFD analysis to evaluate blood flow dynamics in the aorta.
Main Results:
- The patient experienced worsening mesenteric malperfusion despite surgical fenestration.
- CFD analysis identified persistent false lumen flow and true lumen compression.
- A large entry tear and residual proximal anastomotic stenosis were implicated in the poor outcome.
Conclusions:
- Inadequate false lumen depressurization can occur due to large entry tears and residual stenosis.
- CFD analysis is a valuable tool for understanding the hemodynamic consequences of fenestration techniques.
- Optimizing fenestration techniques is crucial to prevent persistent malperfusion in aortic dissection.

