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Updated: Sep 19, 2025

Adapting 3' Rapid Amplification of CDNA Ends to Map Transcripts in Cancer
Published on: March 28, 2018
Recent advances in the study of 3' untranslated regions of eukaryotic mRNAs
Hao-Yu Luo1,2,3, Xiao-Hong Yan1,2,3, Fang Mu1,2,3
1Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Harbin 150030, China.
Abstract:
The 3' untranslated regions (3'UTRs) are a component of eukaryotic messenger RNAs (mRNAs) and located at their 3'-most ends. 3'UTRs play crucial roles in post-transcriptional regulation of gene expression, regulating cleavage and polyadenylation, mRNA stability, mRNA translation and localization. With deepening research of the 3'UTRs, and with advent of various omics methods, a few unexpected functions of the eukaryotic 3'UTRs have been uncovered. In this review, we summarize recent advances in the study of 3'UTRs and propose the future research directions for studying the roles and mechanisms of the 3'UTRs, with the aim to provide a better reference for comprehensively investigating gene function and regulation.
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