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Updated: Sep 19, 2025

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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Application of Free Energy Perturbation (FEP) Methodology for Predicting the Binding Affinity of Macrocyclic JAK2

Natércia F Braz1, Martin J Slater1, Stuart Lang1

  • 1New Cambridge House, Bassingbourn Road, Litlington, Cambridgeshire SG8 0SS, U.K.

ACS Medicinal Chemistry Letters
|June 18, 2025
PubMed

Keywords:
ConformationFEPJAK2KinaseMacrocyclePacritinib

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