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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
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Integrated multidisciplinary approach to aneurysm hemodynamic analysis: numerical simulation, in Vitro experiment,
Tingting Fan1, Jinhang Wang1, Xu Wang2,3
1School of Biomedical Engineering, Capital Medical University, Beijing, China.
Frontiers in Bioengineering and Biotechnology
|June 18, 2025
Summary
This review explores how blood flow dynamics (hemodynamics) impact aneurysm development and progression. It highlights advanced methods for analysis and aims to improve patient-specific risk assessment for better clinical interventions.
Area of Science:
- Cardiovascular Science
- Biomedical Engineering
- Computational Fluid Dynamics
Background:
- Aneurysms are life-threatening vascular diseases significantly influenced by hemodynamics.
- Numerical simulations and in vitro experiments enable high-precision hemodynamic analysis.
- Deep learning enhances computational efficiency, but challenges remain in biomimetic materials and mechano-biological coupling.
Purpose of the Study:
- To review methodologies for characterizing hemodynamic perturbations in aneurysm progression.
- To elucidate the mechanistic basis of aneurysm destabilization.
- To inspire standardized hemodynamic analysis protocols and patient-specific risk stratification.
Main Methods:
- Systematization of traditional and emerging methodologies for hemodynamic analysis.
- Integration of numerical simulation, in vitro experiments, and deep learning.
- Analysis across the pathophysiological continuum: expansion, rupture, and thrombosis.
Main Results:
- Hemodynamic factors are critical in aneurysm development and progression.
- Advanced computational and experimental techniques are improving analysis.
- Gaps exist in biomimetic materials and understanding mechano-biological coupling.
Conclusions:
- Understanding hemodynamic perturbations is key to elucidating aneurysm destabilization.
- Standardized protocols are needed for accurate hemodynamic analysis.
- Data-driven clinical interventions and patient-specific risk stratification are the future.
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