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Increased uric acid to high-density lipoprotein ratio positively correlated with stroke risk

Tieshi Zhu1, Yong He2, Erxinxian Bei1,3

  • 1Department of Neurology, Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang, China.

Frontiers in Neurology
|June 18, 2025
PubMed

Insights

The Uric Acid-to-HDL Ratio (UHR) is linked to a higher stroke risk. This study found a significant positive correlation between UHR and stroke, emphasizing its potential as a predictive marker.

Area of Science:

  • Cardiovascular Health
  • Metabolic Syndrome
  • Neurology

Background:

  • The Uric Acid-to-HDL Ratio (UHR) is a novel index associated with hypertension and diabetes.
  • Previous research linked UHR to ischemic heart disease and coronary artery function.
  • Limited studies have explored the association between UHR and stroke risk.

Purpose of the Study:

  • To investigate the relationship between UHR and the risk of stroke.
  • To assess the nonlinear association between UHR and stroke incidence.
  • To determine if UHR can serve as a predictive marker for stroke.

Main Methods:

  • Analysis of data from 33,192 individuals in the NHANES 1999-2023 database.
  • Utilized restricted cubic spline (RCS) analysis to evaluate nonlinear relationships.
  • Employed logistic regression to assess UHR as a continuous variable and by quartiles.

Main Results:

  • UHR showed a significant positive association with stroke risk (OR=1.02, 95% CI 1.01-1.03).
  • Individuals in the highest quartile of UHR had a 31% increased risk of stroke (OR=1.31, 95% CI 1.11-1.55).
  • The association was linear, not nonlinear (p for nonlinearity=0.65).

Conclusions:

  • A significant positive correlation exists between UHR and stroke risk.
  • Elevated UHR levels are associated with an increased likelihood of experiencing a stroke.
  • UHR may be a valuable biomarker for stroke risk assessment.
Abstract

Keywords:
NHANESUHRcross sectional studypublic healthstroke

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