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Safranal Alleviates Cyclophosphamide Induced Testicular Toxicity in Rats.

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Safranal, derived from saffron, protects against chemotherapy-induced reproductive toxicity. This study shows safranal can mitigate cyclophosphamide

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Area of Science:

  • Reproductive Toxicology
  • Pharmacology
  • Natural Product Chemistry

Background:

  • Cyclophosphamide (CP) is a chemotherapy drug known to cause male reproductive toxicity.
  • Safranal is the main aromatic compound in saffron (Crocus sativus).

Purpose of the Study:

  • To evaluate the protective effects of safranal against CP-induced testicular toxicity in Wistar albino rats.

Main Methods:

  • Rats were treated with CP (15 mg/kg weekly) to induce toxicity.
  • The treatment group received safranal (200 mg/kg daily) concurrently.
  • Spermatological, biochemical, and histological analyses were conducted.

Main Results:

  • CP treatment increased abnormal sperm ratios and reduced sperm quality.
  • CP elevated oxidative stress markers (NF-κB, IL-6, TNF-α, MDA) and decreased antioxidant levels (Nrf-2, GSH, GSH-Px).
  • Safranal administration significantly reversed these adverse effects.

Conclusions:

  • Safranal exhibits significant protective and therapeutic effects against cyclophosphamide-induced reproductive toxicity.
  • Safranal may serve as a beneficial supportive agent during chemotherapy to protect male reproductive health.