Related Experiment Video
Updated: Sep 19, 2025
Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
Malignant pleural effusion is a negative prognostic factor for immunotherapy outcomes in non-small cell lung cancer:
Jing Wang1, Boyue Pang1, Jiali Zhang1
1Key Laboratory of Cancer Immunology and Biotherapy, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
Background:
Malignant pleural effusion (MPE) is a common metastatic site in non-small cell lung cancer (NSCLC) and is associated with poor prognosis. However, data on MPE in the context of immunotherapy are limited. This study aimed to evaluate the clinical outcomes of NSCLC patients with MPE undergoing immunotherapy.
Methods:
This study included NSCLC patients treated with immune checkpoint inhibitors (ICIs) at Tianjin Medical University Cancer Institute & Hospital from January 2018 to August 2024. The presence of cytologically confirmed MPE was defined as the MPE group, against which the absence of pleural effusion was defined as the control group. The primary endpoints were overall survival (OS) and progression-free survival (PFS).
Results:
A total of 167 NSCLC patients treated with ICIs were included, with 84 in the MPE group and 83 in the control group. There were statistically significant differences in PFS and OS between the MPE and control groups (both P<0.05). The median follow-up was 18 months. The median PFS in the MPE group was 9.50 months [95% confidence interval (CI): 7.08-11.92], while in the control group, the median PFS was 16.50 months (95% CI: 8.74-24.26). The median OS in the MPE group was 20.0 months (95% CI: 15.61-24.39), while in the control group, the median OS was 32.0 months (95% CI: 18.11-45.89).
Conclusions:
MPE remains an independent risk factor for poor prognosis in NSCLC even after immunotherapy.
More Related Videos
Related Concept Videos
01:28Pleural Effusion II: Symptoms and Management
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
01:25Pleural Effusion I: Introduction
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
01:27Tumor Immunotherapy