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Genetic profiling and precision skin care: a review
Barbara Geusens1, Diala Haykal2
1Nomige, Gent, Belgium.
Frontiers in Genetics
|June 18, 2025
Summary
Genetic factors significantly influence skin aging, accounting for up to 60% of variability. Understanding genes like ELN, FLG, and MC1R is key for personalized anti-aging strategies.
Area of Science:
- Dermatology
- Genetics
- Aging Research
Background:
- Skin aging is a complex process influenced by intrinsic and extrinsic factors.
- Genetic predisposition significantly contributes to skin aging variability, with estimates up to 60% in certain populations.
- Key genes like elastin (ELN), filaggrin (FLG), and melanocortin 1 receptor (MC1R) are implicated in skin elasticity, hydration, and pigmentation.
Purpose of the Study:
- To review the current understanding of genetic determinants in skin aging.
- To highlight recent discoveries and proposed functional pathways for targeted interventions.
- To discuss future directions in genetic research for clinical and aesthetic dermatology.
Main Methods:
- Literature review of current research on genetic factors in skin aging.
- Analysis of gene functions related to skin structure and appearance.
- Exploration of personalized and targeted intervention strategies based on genetic profiles.
Main Results:
- Genetic factors are major contributors to skin aging, influencing elasticity, hydration, and pigmentation.
- Specific genes (ELN, FLG, MC1R) play critical roles in intrinsic and extrinsic skin aging pathways.
- Individual and ethnic variations in genetic makeup lead to diverse aging phenotypes.
Conclusions:
- Understanding genetic determinants of skin aging is crucial for developing personalized anti-aging therapies.
- Targeted interventions based on genetic insights hold transformative potential in dermatology.
- While genetics are significant, modifiable lifestyle and environmental factors also play a crucial role in overall skin aging.
Keywords:
dermageneticsepigeneticsgenetic profilingmulti-omicspolygenic risk scoresprecision dermatologyskin agingMore Related Videos
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