Related Experiment Video
Updated: Sep 19, 2025
Imaging of the Microstructural Failure Mechanism in the Human Hip
Published on: September 29, 2023
Novel Proteomic Insights into Hip Fractures in the Elderly: Unraveling Immunologic Biomarkers, Temporal Expression
Yining Lu1,2, Jiaoran Liu3, Wei Chen1
1Department of Orthopedic Research Center, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Background:
Hip fractures in the elderly triggers a severe inflammatory immune response.
Methods:
Peripheral blood samples from 16 elderly hip fracture patients and 16 healthy controls were analysed for 92 inflammatory biomarkers using proximity extension assay (PEA) at different stages after trauma.
Results:
Dynamic trends in inflammatory proteins after surgery were assessed. Correlation analyses showed significant associations between inflammation-related proteins and clinical parameters. A prognostic risk score model was developed: on day 1, CCL19, FGF-19 and MCP-2 were significant; on day 3, TGF-α, FGF-5, CCL19, IL-22RA1 and IL-12B were included; and on day 7, IL-2RB, CCL19 and 4E-BP1 were significant. High-risk patients had a significantly lower rate of recovery compared with low-risk patients.
Conclusion:
In this study, we have highlighted the complex inflammatory response during fracture healing and emphasised the importance of long-term monitoring of protein dynamics.
Related Concept Videos
01:27Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:33Proteomics
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...