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Updated: Sep 19, 2025
Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
Published on: January 9, 2019
Imaging characteristics of central neurocytomas according to Ki-67 proliferation index
Yan-Li Zhang1, Ling Liu2, Wei Li3
1Department of Clinical Pharmacy, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Purpose:
To evaluate the imaging characteristics of central neurocytoma (CN) with different Ki-67 indices and reveal its biological behavior.
Materials And Methods:
Sixty-nine cases of intraventricular CN confirmed by histopathology were collected retrospectively. According to Ki-67 indices, they were divided into CNs with high Ki-67 (30 cases) and CNs with low Ki-67 (39 cases). Their clinical and imaging findings were compared and analyzed.
Results:
Compared to CNs with low Ki-67, CNs with high Ki-67 were larger (P < 0.001) and more solid (P = 0.019). Restricted diffusion (P = 0.020), CT hyperdensity (P < 0.001), abnormal vessels (P = 0.018), and marked MRI enhancement (P < 0.001) were more common in CNs with high Ki-67.
Conclusion:
Different Ki-67 indices could affect the imaging characteristics of CNs. Tumor size, radiologic solidity, abnormal vessels, and marked MRI enhancement suggested CNs with high Ki-67. Combining these imaging characteristics and Ki-67 indices offered meaningful insights into their clinical diagnosis and biological behavior.
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