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Updated: Sep 19, 2025
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Published on: August 31, 2015
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Curcumin and selenium synergistically mitigate oxidative stress in white-feathered broilers.
Zixuan He1,2, Zhaoyan Lin1,2, Ye Yan1,2
1College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou, China.
Frontiers in Veterinary Science
|June 18, 2025
Summary
Curcumin and selenium show synergistic antioxidant effects in broilers, improving health by reducing oxidative stress. This combination enhances antioxidant capacity and protects liver and heart tissues via the IGF-1/PI3K/AKT/mTOR pathway.
Area of Science:
- Poultry Science
- Oxidative Stress Research
- Nutritional Biochemistry
Background:
- Oxidative stress is a significant threat to chicken health and the poultry industry.
- Curcumin (CUR) and selenium (Se) possess known antioxidant properties.
- The combined effects of CUR and Se in broilers have not been previously investigated.
Purpose of the Study:
- To investigate the synergistic antioxidant effects of CUR and Se in vitro and in vivo.
- To elucidate the underlying molecular mechanisms of their combined antioxidant action.
Main Methods:
- Experiments utilized the DF-1 cell line and 400 White-feathered Broilers.
- Oxidative stress was induced using hydrogen peroxide (H₂O₂) and dexamethasone (Dex).
- Assessed antioxidant capacity, tissue damage markers, apoptosis, and protein expression levels.
Main Results:
- CUR and Se demonstrated synergistic antioxidant effects in DF-1 cells (Combination Index < 1).
- Combined treatment increased total antioxidant capacity and superoxide dismutase (SOD) activity.
- Decreased lactate dehydrogenase (LDH) and malondialdehyde (MDA) levels, alleviating tissue injury and apoptosis in broilers.
Conclusions:
- CUR and Se synergistically alleviate oxidative stress in White-feathered Broilers.
- The observed synergistic effects are mediated through the IGF-1/PI3K/AKT/mTOR signaling pathway.
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