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Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

249
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
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Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
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Pulmonary Tuberculosis I01:29

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
335
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

389
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
389
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

459
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
459

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Related Experiment Video

Updated: Sep 19, 2025

Matrix-based DNA Extraction for Targeted Next-Generation Sequencing on Decontaminated Sputum Samples
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Matrix-based DNA Extraction for Targeted Next-Generation Sequencing on Decontaminated Sputum Samples

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Data-driven targets for reducing the global burden of TB.

C R Horsburgh1,2,3, Helen E Jenkins3, L Martinez1

  • 1Department of Epidemiology, Boston University School of Public Health Boston MA USA.

IJTLD Open
|June 18, 2025
PubMed
Summary

To reduce tuberculosis (TB) prevalence, at least 20% of infectious TB cases must be cured annually. Achieving the End TB goal requires curing 35-40% of prevalent TB cases each year.

Keywords:
TB incidenceTB prevalenceTB reductiontuberculosis

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Area of Science:

  • Epidemiology
  • Public Health
  • Infectious Disease Control

Background:

  • Understanding the cure rate needed to reduce tuberculosis (TB) prevalence is crucial for effective TB control strategies.
  • Current targets for TB reduction are not well-defined regarding the proportion of infectious cases requiring treatment.

Purpose of the Study:

  • To determine the proportion of infectious TB cases that need to be cured to achieve a reduction in TB prevalence.
  • To establish targets for TB control aligned with the End TB goals.

Main Methods:

  • Compared infectious TB prevalence data from population-based surveys in multiple countries conducted since 2000.
  • Estimated annual incidence by analyzing changes in prevalence over time, accounting for treatment, death, and natural recovery.
  • Assessed the correlation between the TB cure proportion and the observed decrease in prevalence.

Main Results:

  • A minimum of 20% of infectious TB cases must be cured annually to observe a decline in prevalence.
  • No studied countries achieved the 11% annual prevalence decline necessary for the End TB goal.
  • Reaching the End TB goal of 90% prevalence reduction over 20 years necessitates curing 35-40% of prevalent TB cases yearly.

Conclusions:

  • The study provides specific targets for TB cure rates to meet the 90% prevalence reduction goal.
  • Active case-finding strategies are essential to achieve the high diagnosis and cure rates required for TB elimination.