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Circulating membrane vesicles in leukemic blood.

J M Carr, A M Dvorak, H F Dvorak

    Cancer Research
    |November 1, 1985
    PubMed
    Summary
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    Ultramicroscopic membrane vesicles were detected in the plasma of leukemia patients and guinea pigs with leukemia. These vesicles shared antigens with leukemic cells but showed weak procoagulant activity, with no clear link to clinical coagulopathies.

    Area of Science:

    • Hematology
    • Oncology
    • Cell Biology

    Background:

    • Circulating membrane vesicles are implicated in various physiological and pathological processes.
    • Their presence and role in different types of leukemia require further investigation.

    Purpose of the Study:

    • To investigate the presence and characteristics of ultramicroscopic membrane vesicles in leukemia patients and animal models.
    • To explore the potential origin and functional significance of these vesicles, particularly their procoagulant activity.

    Main Methods:

    • Detection and characterization of plasma vesicles using immunofluorescence and biochemical assays.
    • Serial monitoring of vesicle levels in relation to disease activity.
    • Assessment of vesicle procoagulant activity and correlation with platelet counts and clinical coagulopathies.

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    Main Results:

    • Ultramicroscopic membrane vesicles were identified in 17 leukemia patients and in guinea pigs with L2C leukemia.
    • These vesicles shared antigens with L2C leukemic cells and exhibited variable, generally weak procoagulant activity.
    • Vesicle levels paralleled disease activity in serial studies, and they were absent in healthy individuals and patients with other hematological disorders or solid tumors.

    Conclusions:

    • Circulating ultramicroscopic membrane vesicles are associated with specific types of leukemia.
    • While sharing antigens with leukemic cells, their procoagulant activity is weak and does not appear to directly cause clinical coagulopathies in leukemia.