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UNC0638 inhibits SARS-CoV-2 entry by blocking cathepsin L maturation

Yongjun Chen1,2, Yujin Shi1,2, Xiaoyan Zuo1,2

  • 1NHC Key Laboratory of System Biology of Pathogens, Christophe Mérieux Laboratory National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Journal of Virology
|June 18, 2025
PubMed
Summary

EHMT2 is a key host factor for SARS-CoV-2 infection. EHMT2 inhibitors block viral entry by preventing cathepsin L maturation, offering a potential strategy for broad-spectrum coronavirus therapies.

Keywords:
EHMT2SARS-CoV-2UNC0638cathepsin Lviral entry

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