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Updated: Sep 19, 2025
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Hydrolysis of a Ni-Schiff-Base Complex Using Conditions Suitable for Retention of Acid-labile Protecting Groups
Published on: April 6, 2017
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Sustainable Approaches for the Protection and Deprotection of Functional Groups
Isaac Choi1,2, Ju Ha Jin1, Mina An1
1Department of Chemistry, Chungbuk National University, Chungcheongbuk-do, 28644, Republic of Korea.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|June 18, 2025
Summary
This review covers electrochemical and photochemical methods for protecting and deprotecting functional groups in organic synthesis. These sustainable approaches offer mechanistic diversity and broad synthetic utility for complex molecule construction.
Area of Science:
- Organic Chemistry
- Synthetic Methodology
- Sustainable Chemistry
Background:
- Functional group tolerance is crucial in synthetic method development, but many groups are sensitive to reaction conditions.
- Protecting and deprotecting functional groups are established strategies for selective synthesis.
- Sustainable synthetic methods like electrochemistry and photochemistry are gaining importance.
Purpose of the Study:
- To review electrochemical and photochemical strategies for functional group protection and deprotection.
- To highlight the mechanistic diversity, sustainability, and synthetic utility of these methods.
- To provide insights into applying these techniques across various functional group classes.
Main Methods:
- Exploration of electrochemical methods for protection/deprotection.
- Investigation of photochemical methods for protection/deprotection.
- Analysis of mechanistic pathways and reaction conditions.
Main Results:
- Electrochemical and photochemical methods offer sustainable alternatives for functional group manipulation.
- These methods demonstrate significant mechanistic diversity.
- Broad synthetic utility is observed across various functional group classes.
Conclusions:
- Electrochemical and photochemical strategies represent powerful and sustainable tools for organic synthesis.
- These methods enhance selectivity and efficiency in protecting and deprotecting functional groups.
- Further development in these areas promises advancements in complex molecule synthesis.
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