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Association between left ventricular subclinical dysfunction and myocardial abnormalities in Kawasaki disease

Lei Hu1,2, Ran Sun1,2, Zhongqin Zhou1,2

  • 1Department of Radiology, West China Second University Hospital of Sichuan University, Chengdu, 610041, China.

Pediatric Radiology
|June 18, 2025
PubMed

Insights

Kawasaki disease patients without coronary artery dilation show subclinical cardiac dysfunction. Myocardial abnormalities, indicated by altered T1 values, are linked to reduced global longitudinal strain in these patients.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Medical Imaging

Background:

  • Subclinical cardiac dysfunction is linked to coronary artery dilation in Kawasaki disease.
  • Cardiac function and myocardial characteristics are understudied in Kawasaki disease patients without coronary artery dilation.

Purpose of the Study:

  • Evaluate cardiac dysfunction and myocardial tissue characteristics in Kawasaki disease patients without coronary artery dilation using cardiac MRI.
  • Investigate the association between subclinical dysfunction and myocardial abnormalities.

Main Methods:

  • Retrospective enrollment of 72 Kawasaki disease patients (no coronary artery dilation) and 30 controls.
  • Comparison of strain parameters and mapping values between groups using cardiac MRI.
  • Analysis of global longitudinal strain and global native T1 values.

Main Results:

  • Kawasaki disease patients exhibited lower global longitudinal strain (-13.2±3.9%) compared to controls (-15.1±4.2%).
  • Global native T1 values were higher in Kawasaki disease patients (1306.5±75.2 ms) versus controls (1264.3±65.5 ms).
  • Global native T1 value correlated with global longitudinal strain (r=0.22, P<0.01) and was independently associated (β=0.11, P=0.01).

Conclusions:

  • Kawasaki disease patients without coronary artery dilation experience subclinical cardiac dysfunction.
  • Myocardial abnormalities, evidenced by altered T1 mapping, are associated with impaired longitudinal strain in the chronic phase.
Abstract

Keywords:
ChildMagnetic resonance imagingMucocutaneous lymph node syndromeMyocardiumVentricular function

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