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Updated: Sep 19, 2025

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
Published on: February 23, 2017
Phosphate-driven microstructural evolution of hydroxyapatite
Yin-Chuan Wang1,2,3,4, Lin-Mao Ma5, Hong-Jin Xue1,2
1School of Radiology, The Second Affiliated Hospital of Shandong First Medical University, Taian, 271016, China.
None:
The microstructure, composition, and size of hydroxyapatite (HA) are key factors influencing its physicochemical properties and potential applications. However, research on the impact of the intrinsic physicochemical properties of phosphates on the HA microstructure remains limited. Herein, one-dimensional (1D) HA nanofibers and three-dimensional (3D) microspheres were successfully synthesized using ricinoleic acid-assisted solvothermal synthesis with three different phosphate sources (NaH2PO4·2H2O, Na5P3O10, and (NaPO3)6). XRD, SEM, and TEM analyses revealed that NaH2PO4·2H2O favors the formation of ultralong flexible HA nanofibers that preferentially grow along the c-axis, whereas (NaPO3)6 inhibits c-axis growth and promotes the formation of nanorod self-assembled microspheres. Based on these findings, a mechanism was proposed to explain the phosphate-mediated regulation of HA microstructural evolution from 1D nanofibers to 3D microspheres.
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