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Phosphate-driven microstructural evolution of hydroxyapatite.

Yin-Chuan Wang1,2,3,4, Lin-Mao Ma5, Hong-Jin Xue1,2

  • 1School of Radiology, The Second Affiliated Hospital of Shandong First Medical University, Taian, 271016, China.

Dalton Transactions (Cambridge, England : 2003)
|June 18, 2025
PubMed
Summary
This summary is machine-generated.

Different phosphate sources influence hydroxyapatite (HA) microstructure. Sodium dihydrogen phosphate yields ultralong nanofibers, while sodium hexametaphosphate forms 3D microspheres, revealing phosphate-mediated HA structural control.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomaterials Engineering

Background:

  • Hydroxyapatite (HA) properties are dictated by its microstructure, composition, and size.
  • Limited research exists on how phosphate precursors affect HA microstructure.

Purpose of the Study:

  • To investigate the influence of different phosphate sources on hydroxyapatite (HA) microstructure.
  • To elucidate the mechanism of phosphate-mediated HA structural evolution.

Main Methods:

  • One-dimensional (1D) HA nanofibers and three-dimensional (3D) microspheres synthesized via ricinoleic acid-assisted solvothermal method.
  • Utilized three distinct phosphate sources: NaH2PO4·2H2O, Na5P3O10, and (NaPO3)6.
  • Characterization using X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and Transmission Electron Microscopy (TEM).

Main Results:

  • NaH2PO4·2H2O promoted the formation of ultralong, flexible HA nanofibers with preferential c-axis growth.
  • (NaPO3)6 inhibited c-axis growth, leading to the self-assembly of nanorods into 3D microspheres.
  • Na5P3O10 resulted in intermediate structures, demonstrating a dose-dependent effect.

Conclusions:

  • Phosphate precursors play a critical role in regulating HA's 1D to 3D microstructural transformation.
  • A mechanism for phosphate-mediated control over HA morphology was proposed.
  • Findings offer insights for tailoring HA properties for specific applications.