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Inflammation-related polymorphisms IFNG-AS1 rs1558744 and CCAT2 rs6983267: Potential risk factors for ulcerative
Dilek Sari-Tiric1, Seda Orenay-Boyacioglu2, Elmas Kasap3
1School of Medicine, Department of Endocrinology and Metabolic Diseases, Atatürk University, Erzurum, Türkiye.
Summary
Polymorphisms in IFNG-AS1 and CCAT2 genes may increase the risk of developing ulcerative colitis (UC). This study investigated inflammation-related long non-coding RNA (lncRNA) gene variants in UC patients and healthy controls.
Area of Science:
- Genetics
- Molecular Biology
- Gastroenterology
Background:
- Long non-coding RNAs (lncRNAs) are implicated in inflammatory processes.
- The role of lncRNAs in ulcerative colitis (UC) pathogenesis is not fully understood.
- Investigating lncRNA polymorphisms may reveal insights into UC development.
Purpose of the Study:
- To determine the association between inflammation-related lncRNA polymorphisms and UC.
- To explore the potential role of these genetic variations in UC pathogenesis.
Main Methods:
- Case-control study involving 73 UC patients and 73 healthy controls.
- Genotyping of specific lncRNA polymorphisms (ANRIL, IFNG-AS1, LINC01430, LOC101926945, CCAT2) using Fluidigm SNP Type.
- Analysis of genotype and allele frequencies in relation to UC status.
Main Results:
- Statistically significant differences in genotype distributions for IFNG-AS1 (rs1558744) and CCAT2 (rs6983267) polymorphisms between UC patients and controls (p=0.042, p=0.033).
- Significant allele frequency difference for IFNG-AS1 rs1558744 polymorphism (p=0.040).
- No significant associations found between polymorphisms and UC disease location, activity, or duration.
Conclusions:
- IFNG-AS1 rs1558744 and CCAT2 rs6983267 polymorphisms are potential risk factors for UC development.
- Further research is warranted to elucidate the precise mechanisms.
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