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Apoptotic effect of carvacrol on different cancer cells and its potential as an active medicine ingredient

Müge Musmula1, Senem Akkoc2,3

  • 1Faculty of Medicine, Department of Medical Pharmacology, Suleyman Demirel University, Institute of Health Sciences, Isparta 52994, Türkiye.

Journal of Asian Natural Products Research
|June 18, 2025
PubMed

Insights

Carvacrol, a natural compound, inhibits tumor growth by triggering programmed cell death (apoptosis) in cancer cells. It enhances cancer cell death markers and shows potential as an anti-cancer drug.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Apoptosis is crucial for eliminating damaged or unnecessary cells.
  • Overexpression of apoptosis-regulating genes is implicated in tumor development.
  • Carvacrol is a natural terpenoid with known anti-cancer properties.

Purpose of the Study:

  • To review the effects of carvacrol on various types of cancer.
  • To summarize carvacrol's potential as a therapeutic agent for cancer treatment.

Main Methods:

  • Literature review of studies on carvacrol and cancer.
  • Analysis of carvacrol's molecular mechanisms in inducing apoptosis.

Main Results:

  • Carvacrol inhibits tumor growth and induces apoptosis in cancer cells.
  • It increases caspase activity and DNA fragmentation.
  • Carvacrol upregulates Bax protein expression and downregulates Bcl-2 expression.

Conclusions:

  • Carvacrol demonstrates significant potential as an anti-cancer drug.
  • Its ability to induce apoptosis makes it a promising candidate for cancer therapy.
Keywords:
Carvacrolanticancer agentsapoptosiscancer

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