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Zebrafish sperm outsource activation to eggs' protease-activated receptors

Rafael A Fissore1, Emily M Lopes1,2, Francesca Carpentiero1

  • 1Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts, United States of America.

Plos Biology
|June 18, 2025
PubMed
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During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...