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TSHR in thyroid cancer: bridging biological insights to targeted strategies

Shaojie Xu, Youyun Peng, Xingyin Li

    European Thyroid Journal
    |June 18, 2025
    PubMed

    Insights

    Thyroid-stimulating hormone receptor (TSHR) is a potential target for thyroid cancer treatment. Optimizing TSHR-targeted drugs may offer new options for radioiodine-refractory differentiated thyroid cancer.

    Area of Science:

    • Endocrinology
    • Oncology
    • Molecular Biology

    Background:

    • Thyroid-stimulating hormone receptor (TSHR) traditionally enhances radioactive iodine therapy efficacy by increasing iodine uptake.
    • Personalized medicine trends necessitate re-evaluating TSHR's therapeutic potential beyond its traditional role.

    Purpose of the Study:

    • To review the biological characteristics of TSHR.
    • To explore TSHR's potential as a therapeutic target for thyroid cancer, especially radioiodine-refractory differentiated thyroid cancer (RAIR-DTC).

    Main Methods:

    • Literature review focusing on TSHR's role in thyroid cancer progression.
    • Analysis of TSHR's potential as a therapeutic target in the context of personalized medicine.

    Main Results:

    • TSHR plays a critical role in thyroid cancer progression.
    • TSHR is a promising target for treating residual or metastatic thyroid cancers, particularly RAIR-DTC.

    Conclusions:

    • Optimizing TSHR-targeted drugs is crucial.
    • Integrating TSHR-targeted therapies with existing strategies may provide new treatment avenues for RAIR-DTC patients.
    Keywords:
    TSHRdifferentiated thyroid cancerradioiodine-refractory differentiated thyroid cancertargeted strategies

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