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Updated: Sep 19, 2025

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
Single nucleotide variants of the SLC2A2 gene in Mexican-origin population
Christopher A Gutiérrez-García1, Martín R Gutiérrez-Jiménez1, Roberto de J Sandoval-Muñiz2
1Centro Universitario de Tonalá, Universidad de Guadalajara.
Background:
Diabetes, which is caused by environmental and genetic factors, has a high global prevalence (10.5%). Some single nucleotide variants (SNVs) modify the activity of glucose transporters such as GLUT2, which plays a significant role in insulin secretion and glucose metabolism.
Objective:
To analyze the SNVs associated with type 2 diabetes (T2D) in the Mexican population.
Material And Methods:
Reference databases for SNVs registered for SLC2A2 gen associated with T2DM in the Mexican population.
Results:
83 SNVs were analyzed, identifying 3 relevant variants in Mexican population associated with T2D: rs5404, rs5406 and rs5398, a pathogenic variant with RM >1.0 and p value < 0.05.
Conclusions:
Detailed genetic analysis and mapping coupled with functional studies are needed to identify the mechanism by which GLUT2 variants influence diabetes development.
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