Recent advances in biosensors for the detection of pancreatic cancer protein markers

Pancreatic cancer, marked by its low five-year survival rate following surgery and rising incidence, has become one of the most lethal malignant tumors. Due to the limitations of conventional diagnostic methods, pancreatic cancer is often diagnosed at advanced stages. Early and minimally invasive detection methods facilitate timely diagnosis and significantly improve survival rates. Developing biosensors with high specificity and sensitivity for detecting protein biomarkers associated with tumor progression represents a promising strategy to achieve this goal. This review provides an overview of various biosensors utilized for detecting pancreatic cancer-related protein biomarkers and biomarker panels. First, it briefly introduces several key protein biomarkers relevant to the clinical detection of pancreatic cancer. Next, it highlights recent advancements in biosensor technology and combined detection methods for improved biomarker identification. Finally, it discusses the challenges and future directions in using biosensors for the early detection of pancreatic cancer.